High cord blood CCL22/CXCL10 chemokine ratios precede allergic sensitization in early childhood

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High cord blood CCL22/CXCL10 chemokine ratios precede allergic sensitization in early childhood

Atopic diseases are known to be characterized by a T helper (Th) 2-skewed immunity; however, there are few studies addressing the Th1/Th2 immunity at birth related to the development of atopic diseases in early childhood. We investigated 186 children followed up regularly at the clinic for 4 years in a birth cohort study. The Th1-associated CXC chemokine ligand (CXCL)-10, CXCL11, and the Th2-as...

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Early-life nutrition is an important modifiable determinant in the development of a child's immune system, and may thereby influence the risk of allergic sensitization and atopic diseases. However, associations between overall dietary patterns and atopic diseases in childhood remain unclear. We examined associations of diet quality in early life with allergic sensitization, self-reported physic...

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Early childhood overweight and asthma and allergic sensitization at 8 years of age.

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raised interleukin-13 levels in cord blood increases the risk of allergic sensitization at 5 years of age.

the identification of early markers of atopy in cord blood of newborns at delivery may offer prediction of future allergic sensitization. the aim of this study was to evaluate the relationship between cord blood interleukin-13 (il-13) and interferon-gamma (ifn-γ) and development of allergic diseases during the first five years of life. umbilical cord blood samples were collected at the time of ...

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ژورنال

عنوان ژورنال: Oncotarget

سال: 2016

ISSN: 1949-2553

DOI: 10.18632/oncotarget.13374